BIO 5192
Tocris Bioscience, part of Bio-Techne | Catalog # 5051
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
Key Product Details
Description
Highly potent and selective inhibitor of integrin α4β1 (VLA-4)
Product Description
BIO 5192 is a highly selective and potent inhibitor of integrin α4β1 (Very Late Antigen-4; VLA-4) (Kd < 10 pM). Selectively binds α4β1 over a range of other integrins (IC50 values are 1.8, 138, 1053, > 500 and > 10,000 nM for α4β1, α9β1, α2β1, α4β7 and αIIbβ3, respectively). Induces a 30-fold increase in mobilization of murine hematopoietic stem and progenitor cells; displays a 3-fold additive effect with AMD 3100 (Cat. No. 3299). Decreases oxidative damage and improves neurological function following spinal cord injury in rats.Product Specifications
Molecular Weight
817.78
Formula
C38H46Cl2N6O8S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2S)-2-[[[(2S)-1-[(3,5-Dichlorophenyl)sulfonyl]-2-pyrrolidinyl]carbonyl]amino]-4-[[(2S)-4-methyl-2-[methyl[2-[4-[[[(2-methylphenyl)amino]carbonyl]amino]phenyl]acetyl]amino]-1-oxopentyl]amino]butanoic acid
CAS Number
327613-57-0
PubChem ID
10350459
InChI Key
MNQBPRHHZPXCKZ-ZDCRTTOTSA-N
SMILES
O=C(NC2=CC=C(CC(N(C)[C@@H](CC(C)C)C(NCC[C@@H]([C@@](O)=O)N[C@]([C@H]3N(S(C4=CC(Cl)=CC(Cl)=C4)(=O)=O)CCC3)=O)=O)=O)C=C2)NC1=CC=CC=C1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 81.78 | 100 |
Preparing Stock Solutions
for BIO 5192
The following data is based on the product molecular weight 817.78
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.22 mL | 6.11 mL | 12.23 mL |
| 5 mM | 0.24 mL | 1.22 mL | 2.45 mL |
| 10 mM | 0.12 mL | 0.61 mL | 1.22 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.24 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bao An integrin inhibiting molecule decreases oxidative damage and improves neurological function after spinal cord injury. Exp.Neurol 2008 PMID: 18926823
- Xu A chemical approach to stem-cell biology and regenerative medicine. Nature 2008 PMID: 18480815
- Ramirez BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells. Blood. 2009 PMID: 19571319
- Leone An assessment of the mechanistic differences between two integrin α4β1 inhibitors, the monoclonal antibody TA-2 and the small molecule BIO5192, in rat experimental aut J.Pharmacol.Exp.Ther. 2003 PMID: 12626659
Product Specific Notices for BIO 5192
For research use only
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