BIO 1211
Tocris Bioscience, part of Bio-Techne | Catalog # 3910
Selective α4β1 (VLA-4) inhibitor
Key Product Details
Description
Selective α4β1 (VLA-4) inhibitor
Product Description
BIO 1211 is a selective, high affinity α4β1 (Very Late Antigen 4; VLA-4) inhibitor; displays 200-fold selectivity for the activated form of α4β1 (KD = 70 pM; IC50 = 0.004 μM). Selective for α4β1 over a range of other integrins (IC50 >100 μM for α1β1, α5β1 and α6β1).Product Specifications
Molecular Weight
708.80
Formula
C36H48N6O9
Storage
Store at -20°C
Purity
≥95% (HPLC)
CAS Number
187735-94-0
PubChem ID
9961766
InChI Key
NVVGCQABIHSJSQ-KFZSMJGVSA-N
SMILES
O=C(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C=C2)N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)C)C(N1CCC[C@H]1[C@@](O)=O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 2mg/ml in water |
Calculators
Molarity Calculator
Dilution Calculator
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Background References
References are publications that support the biological activity of the product.
- Lin Selective, tight-binding inhibitors of integrin α4β1 that inhibit allergic airway responses. J.Med.Chem. 1999 PMID: 10072689
- Muro Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist. J.Med.Chem. 2009 PMID: 19891440
- Chen Multiple activation sites of integrin α4β1 detected through their different affinities for a small molecule ligand. J.Biol.Chem. 1999 PMID: 10224072
Product Specific Notices for BIO 1211
For research use only
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