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HIF-1 alpha/HIF1A: Small Molecules and Peptides

The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.

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8 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products

8 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products

HIF-1 alpha/HIF1A: Small Molecules and Peptides

The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environments occur in vascular and pulmonary diseases as well as cancer, which illustrates the broad impact of gene regulation by HIF1A.

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Prolyl hydroxylase inhibitor

Chemical Name: N-(2-Methoxy-2-oxoacetyl)glycine methyl ester
Purity: ≥97% (HPLC)
Prolyl hydroxylase inhibitor

Thioredoxin-1 inhibitor

Alternate Names: IV-2
Chemical Name: 2-[(1-Methylpropyl)dithio]-1H-imidazole
Purity: ≥98% (HPLC)
Thioredoxin-1 inhibitor

HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Chemical Name: N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide
Purity: ≥98% (HPLC)
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis

Highly potent and selective HIF-1α inhibitor

Alternate Names: Quinomycin A
Chemical Name: N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether
Purity: ≥98% (HPLC)
Highly potent and selective HIF-1α inhibitor

Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

Chemical Name: N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine
Purity: ≥98% (HPLC)
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor

HIF α-subunit inhibitor

Chemical Name: 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate
Purity: ≥98% (HPLC)
HIF α-subunit inhibitor

Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Alternate Names: CAY 10585
Chemical Name: Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate
Purity: ≥98% (HPLC)
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α

Inhibitor of VHL; blocks interaction of VHL and HIF-α

Chemical Name: (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Inhibitor of VHL; blocks interaction of VHL and HIF-α
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