EDNRA/Endothelin R Type A: Small Molecules and Peptides
EDNRA and EDNRB (endothelin A and B receptors, respectively) are members of the rhodopsin-like 7-transmembrane receptor family. EDNRA binds endothelins ET-1 and ET-2 preferentially, and is expressed on vascular smooth muscle where it mediates vasoconstriction. EDNRB binds all three endothelin forms equally, and is expressed on endothelial cells where it mediates vasodilation.
3 results for "EDNRA/Endothelin R Type A Small Molecules and Peptides" in Products
3 results for "EDNRA/Endothelin R Type A Small Molecules and Peptides" in Products
EDNRA/Endothelin R Type A: Small Molecules and Peptides
EDNRA and EDNRB (endothelin A and B receptors, respectively) are members of the rhodopsin-like 7-transmembrane receptor family. EDNRA binds endothelins ET-1 and ET-2 preferentially, and is expressed on vascular smooth muscle where it mediates vasoconstriction. EDNRB binds all three endothelin forms equally, and is expressed on endothelial cells where it mediates vasodilation.
High affinity dual ETA and ETB receptor antagonist;orally bioavailable
| Alternate Names: | Ro 47-0203 |
| Chemical Name: | 4-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2'-bipyrimidin]-4-yl]benzenesulfonamide |
| Purity: | ≥98% (HPLC) |
Selective ETA antagonist
| Purity: | ≥95% (HPLC) |
Selective ETA antagonist
| Chemical Name: | (αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid |
| Purity: | ≥98% (HPLC) |
