4 results for "Dihydrofolate Reductase/DHFR Small Molecules and Peptides" in Products
Dihydrofolate Reductase/DHFR: Small Molecules and Peptides
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
Photoswitchable inhibitor of human dihydrofolate reductase
| Chemical Name: | N-[4-[(1E)-2-(2,4-Diamino-6-quinazolinyl)diazenyl]benzoyl]-L-glutamic acid |
| Purity: | ≥95% (HPLC) |
Thymidylate synthetase inhibitor, also inhibits dihydrofolate reductase, GARFT and AICART
| Chemical Name: | N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid |
| Purity: | ≥98% (HPLC) |
Cytotoxic agent
| Chemical Name: | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic acid |
| Purity: | ≥98% (HPLC) |
Potent inhibitor of multidrug and toxin extrusion (MATE) transporters; also DHFR and STAT3 inhibitor
| Chemical Name: | 5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine |
| Purity: | ≥98% (HPLC) |
