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156 results for "Degrader Building Blocks Small Molecules and Peptides" in Products

Degrader Building Blocks: Small Molecules and Peptides

Functionalized VHL building block for copper-free click chemistry

Chemical Name: ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate
Purity: ≥90% (HPLC)
Functionalized VHL building block for copper-free click chemistry

Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

Chemical Name: 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid
Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry

VHL ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-C7-NH2
Chemical Name: (2S,4R)-1-((S)-2-(8-Aminooctanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Purity: ≥95% (HPLC)
VHL ligand with alkyl linker and terminal amine for onward chemistry

Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Purity: ≥95% (HPLC)
Binds to LRP1 and facilitates receptor-mediated transcytosis of cargo across the BBB

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Pomalidomide - linker 8
Chemical Name: 4-[(14-Amino-3,6,9,12-tetraoxatetradec-1-yl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-Isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

Chemical Name: N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry

VHL ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG6-NH2
Chemical Name: (2S,4R)-1-((S)-23-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18,21-hexaoxa-3-azatricosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal amine for onward chemistry

Biotinylated ASGPR ligand for LYTAC research and development

Purity: ≥90% (HPLC)
Biotinylated ASGPR ligand for LYTAC research and development

Negative control for VH 032, amine (Cat. No. 6462)

Alternate Names: (S,S,S)-AHPC
Chemical Name: (2S,4S)-1-[(2S)-2-Amino-3,3-dimethyl-butanoyl]-4-hydroxy-N-[[4-(4-methylthiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide dihydrochloride
Purity: ≥98% (HPLC)
Negative control for VH 032, amine (Cat. No. 6462)

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name: 7-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]heptanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Functionalized IAP ligand for PROTACs

Chemical Name: tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity: ≥95% (HPLC)
Functionalized IAP ligand for PROTACs

Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Chemical Name: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside
Purity: ≥95% (HPLC)
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry

Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Purity: ≥90% (HPLC)
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry

Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Chemical Name: 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control

Functionalized cereblon ligand for PROTAC development

Chemical Name: 3-[[3-(1-Piperazinyl)phenyl]amino]-2,6-piperidinedione dihydrochloride
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Functionalized VHL ligand for PROTACs

Chemical Name: (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride
Purity: ≥98% (HPLC)
Functionalized VHL ligand for PROTACs

Functionalized cereblon ligand for PROTAC development

Chemical Name: 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

Functionalized IAP ligand for PROTACs

Chemical Name: tert-Butyl [(S)-1-[[(S)-2-[(2S,4S)-4-amino-2-[[(R)-1,2,3,4-tetrahydronaphthalen-1-yl]carbamoyl]pyrrolidin-1-yl]-1-cyclohexyl-2-oxoethyl]amino]-1-oxopropan-2-yl](methyl)carbamate hydrochloride
Purity: ≥98% (HPLC)
Functionalized IAP ligand for PROTACs

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Chemical Name: 4-[(3-Aminopropyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names: Pomalidomide - linker 1
Chemical Name: 4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal amine for onward chemistry

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names: Pomalidomide - linker 7
Chemical Name: 4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Chemical Name: 3-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]propanoic acid
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal acid for onward chemistry

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name: 3-[4-[[2-(2-Azidoethoxy)ethyl]amino]-1,3-dihydro-1-oxo-2H-isoindol-2-yl]-2,6-piperidinedione
Purity: ≥95% (HPLC)
Cereblon ligand with PEG linker and terminal azide for onward chemistry

Functionalized cereblon ligand for PROTAC development

Chemical Name: 2-(4-(2,6-Dioxopiperidin-3-yl)phenoxy)acetic acid
Purity: ≥95% (HPLC)
Functionalized cereblon ligand for PROTAC development

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternate Names: (S,R,S)-AHPC-PEG5-COOH
Chemical Name: (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid
Purity: ≥95% (HPLC)
VHL ligand with PEG linker and terminal acid for onward chemistry
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