Degrader Building Blocks: Small Molecules and Peptides
157 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
157 results for "Degrader Building Blocks Small Molecules and Peptides" in Products
Degrader Building Blocks: Small Molecules and Peptides
Functionalized VHL building block for copper-free click chemistry
| Chemical Name: | ((1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-yl)methyl ((S)-14-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-15,15-dimethyl-12-oxo-3,6,9-trioxa-13-azahexadecyl)carbamate |
| Purity: | ≥90% (HPLC) |
Asialoglycoprotein receptor ligand with PEG linker and carboxylic acid group for onward chemistry
| Chemical Name: | 36-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-21,21-bis[[3-[[3-[[5-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-1-oxopentyl]amino]propyl]amino]-3-oxopropoxy]methyl]-19,26,32-trioxo-4,7,10,13,16,23-hexaoxa-20,27,31-triazahexatriacontanoic acid |
| Purity: | ≥90% (HPLC) |
Biotinylated ASGPR ligand for LYTAC research and development
| Purity: | ≥90% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride |
| Purity: | ≥94% (HPLC) |
Asialoglycoprotein receptor ligand with PEG4 linker and azide group for onward chemistry
| Chemical Name: | 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 2-(acetylamino)-2-deoxy-β-D-galactopyranoside |
| Purity: | ≥95% (HPLC) |
Asialoglycoprotein receptor ligands with PEG3 linker and azide group for onward chemistry
| Purity: | ≥90% (HPLC) |
Cereblon ligand with PEG linker and terminal amine for onward chemistry
| Chemical Name: | 4-[[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 5-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal azide for onward chemistry
| Chemical Name: | 4-(5-Azidopentoxy)-2-(2,6-dioxopiperidin-3yl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Functionalized IAP ligand for PROTACs
| Chemical Name: | tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((S)-2-(4-(3-hydroxybenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate |
| Purity: | ≥95% (HPLC) |
Asialoglycoprotein receptor ligand with alkylC5 linker and amine group for onward chemistry
| Chemical Name: | N-[2-[[1-[2-[2-[2-[2-[[2-(Acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]-1,1-bis[[[1-[2-[2-[2-[2-[[2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]ethoxy]ethoxy]ethoxy]ethyl]-1H-1,2,3-triazol-4-yl]methoxy]methyl]ethyl]-6-aminohexanamide |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | Pomalidomide - linker 4 |
| Chemical Name: | 4-[(5-Aminopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with alkyl linker and terminal amine for onward chemistry
| Chemical Name: | 4-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride |
| Purity: | ≥95% (HPLC) |
Fluoro functionalized Thalidomide; cereblon ligand for PROTACs
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% |
VHL ligand with alkyl linker and terminal amine for onward chemistry
| Alternate Names: | VH 032 - linker 8,(S,R,S)-AHPC-C2-NH2 |
| Chemical Name: | (2S,4R)-1-((S)-2-(7-Aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG4-COOH |
| Chemical Name: | (S)-18-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-19,19-dimethyl-16-oxo-4,7,10,13-tetraoxa-17-azaicosanoic acid |
| Purity: | ≥95% (HPLC) |
Functionalized cereblon ligand for generating Degrader negative controls; also used as Pomalidomide negative control
| Chemical Name: | 4-Amino-2-(1-methyl-2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
Functionalized VHL ligand for PROTACs
| Chemical Name: | (4R)-3-Methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-L-prolinamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Functionalized cereblon ligand for PROTAC development
| Chemical Name: | 4-Methyl-3-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)benzoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-fluoro-6-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand with PEG linker and terminal acid for onward chemistry
| Alternate Names: | (S,R,S)-AHPC-PEG5-COOH |
| Chemical Name: | (S)-21-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidine-1-carbonyl)-22,22-dimethyl-19-oxo-4,7,10,13,16-pentaoxa-20-azatricosanoic acid |
| Purity: | ≥95% (HPLC) |
Cereblon ligand with terminal piperidine for onward chemistry
| Chemical Name: | 2-(2,6-Dioxo-3-piperidinyl)-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-1H-isoindole-1,3(2H)-dione dihydrochloride |
| Purity: | ≥95% (HPLC) |
VHL ligand, carboxylic acid functionalized at the benzylic position
| Chemical Name: | (S)-3-[[[(2S,4R)-1-[(S)-2-(1-Fluorocyclopropan-1-ylcarbonylamino)-3,3-dimethylbutanoyl]-4-hydroxypyrrolidin-2-yl]carbonyl]amino]-3-[4-(4-methylthiazol-5-yl)phenyl]propanoic acid |
| Purity: | ≥98% (HPLC) |
Cereblon ligand with PEG linker and terminal azide for onward chemistry
| Chemical Name: | 4-(2-(2-(2-Azidoethoxy)ethoxy)ethoxy)-2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione |
| Purity: | ≥95% (HPLC) |
