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19 results for "Cytokine Compounds" in Products

Cytokine Compounds Products

Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases.

Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune ...

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Antifibrotic agent; regulates cytokine levels in vivo

Chemical Name: 5-methyl-1-phenyl-2(1H)-pyridinone
Purity: ≥98% (HPLC)
Antifibrotic agent; regulates cytokine levels in vivo

Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name: N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity: ≥98% (HPLC)
Binds cereblon; also TNF-α synthesis inhibitor

Selective Syk kinase inhibitor

Chemical Name: 10-(3-Aminopropyl)-3,4-dimethyl-9(10H)-acridinone maleate
Purity: ≥98% (HPLC)
Selective Syk kinase inhibitor

Macrophage migration inhibitory factor (MIF) inhibitor

Chemical Name: 4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester
Purity: ≥98% (HPLC)
Macrophage migration inhibitory factor (MIF) inhibitor

Immunomodulatory and antitumor compound

Chemical Name: 2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone
Purity: ≥98% (HPLC)
Immunomodulatory and antitumor compound

Immunomodulator; reduces production of pro-inflammatory cytokines

Chemical Name: 4,5-Dihydro-3-phenyl-5-isoxazoleacetic acid
Purity: ≥98% (HPLC)
Immunomodulator; reduces production of pro-inflammatory cytokines

Suppressor of MDK expression; inhibits PI 3-K signaling

Chemical Name: 3-[2-[(4-Fluorophenyl)methyl]imidazo[2,1-b]thiazol-6-yl]-2H-1-benzopyran-2-one
Purity: ≥98% (HPLC)
Suppressor of MDK expression; inhibits PI 3-K signaling

Active metabolite binds CPSF3; Pro-drug

Alternate Names: TO-207
Chemical Name: N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
Purity: ≥98% (HPLC)
Active metabolite binds CPSF3; Pro-drug

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name: 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity: ≥98% (HPLC)
Cereblon binder; induces ubiquitination and degradation of CK1α by  E3 ubiquitin ligase

Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

Chemical Name: 4-Iodo-6-phenylpyrimidine
Purity: ≥98% (HPLC)
Inhibitor of macrophage migration inhibitory factor (MIF); suicide substrate

Cereblon binder; also TNF-α inhibitor and antiangiogenic

Chemical Name: 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥98% (HPLC)
Cereblon binder; also TNF-α inhibitor and antiangiogenic

TIR-TIR interaction inhibitor

Chemical Name: 1-Methyl-2,5-bis[[[(1S)-2-methyl-1-(1-pyrrolidinylcarbonyl)propyl](3-phenylpropyl)amino]carbonyl]pyridinium iodide
Purity: ≥98% (HPLC)
TIR-TIR interaction inhibitor

gp130 agonist; brain penetrant and neuroprotectant

Chemical Name: N-(4-Fluorophenyl)-4-phenyl-2-thiazolamine
Purity: ≥98% (HPLC)
gp130 agonist; brain penetrant and neuroprotectant

Potent NLRP3 inflammasome inhibitor

Chemical Name: 2-((1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino)-5-(pyridin-2-ylmethyl)-[1,2,4]triazolo[1,5-a]pyrimidine-7(4H)-thione
Purity: ≥95% (HPLC)
Potent NLRP3 inflammasome inhibitor

MIF binder

Chemical Name: 2-(2-Pyridinyl)-4H-1,3-benzothiazin-4-one
Purity: ≥98% (HPLC)
MIF binder

Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

Alternate Names: FOY
Chemical Name: 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate
Purity: ≥98% (HPLC)
Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

NLRP3 inflammasome inhibitor

Alternate Names: JC121
Chemical Name: N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
Purity: ≥98% (HPLC)
NLRP3 inflammasome inhibitor

Potent and selective IRAK4 inhibitor

Chemical Name: N-[3-Aminocarbonyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl]-2-(2-methyl-4-pyridinyl)-4-oxazolecarboxamide hydrochloride
Purity: ≥98% (HPLC)
Potent and selective IRAK4 inhibitor

TRAF6-Ubc13 interaction inhibitor

Chemical Name: 3-[3,5-Dimethyl-1-(3-methyl-1,2,4-triazolo[4,3-b]pyridazin-6-yl)-1H-pyrazol-4-yl]-1-[4-(phenylmethyl)-1-piperidinyl]-1-propanone
Purity: ≥98% (HPLC)
TRAF6-Ubc13 interaction inhibitor
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