16673-34-0 NLRP3i

Name: 16673-34-0 NLRP3i
Brand: Tocris Bioscience
SKU: 6774

Tocris Bioscience, part of Bio-Techne | Catalog # 6774

COA / SDS

NLRP3 inflammasome inhibitor

Key Product Details

Description:	NLRP3 inflammasome inhibitor
Alternative Names:	JC121
Chemical Name:	N-[2-[4-(Aminosulfonyl)phenyl]ethyl]-5-chloro-2-methoxybenzamide
Purity:	≥98% (HPLC)
Molecular Weight:	368.84

View Full Technical Details for 16673-34-0 NLRP3i

Technical Data
Citations

Biological Activity for 16673-34-0 NLRP3i

16673-34-0 NLRP3i is a NLRP3 inflammasome inhibitor. Inhibits formation of NLRP3 inflammasome and IL-1β release in LPS and ATP-stimulated mouse macrophages and cardiomyocytes in vitro. Inhibits NLRP3 activation in mouse acute myocardial infarction and peritonitis models without affecting plasma glucose levels. Glyburide synthetic intermediate.

Compound Libraries for 16673-34-0 NLRP3i

16673-34-0 NLRP3i is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for 16673-34-0 NLRP3i

M. Wt	368.84
Formula	C₁₆H₁₇ClN₂O₄S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	16673-34-0
PubChem ID	85542
InChi Key	KVWWTCSJLGHLRM-UHFFFAOYSA-N
Smiles	COC1=C(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)C=C(C=C1)Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 16673-34-0 NLRP3i

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	18.44	50

Preparing Stock Solutions for 16673-34-0 NLRP3i

The following data is based on the product molecular weight 368.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.42 mL	27.11 mL	54.22 mL
2.5 mM	1.08 mL	5.42 mL	10.84 mL
5 mM	0.54 mL	2.71 mL	5.42 mL
25 mM	0.11 mL	0.54 mL	1.08 mL

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References for 16673-34-0 NLRP3i

References are publications that support the biological activity of the product.

Fulp Structural insights of benzenesulfonamide analogues as NLRP3 inflammasome inhibitors: design, synthesis, and biological characterization. J.Med.Chem. 2018 PMID: 29877709
Marchetti A novel pharmacologic inhibitor of the NLRP3 inflammasome limits myocardial injury after ischemia-reperfusion in the mouse. J.Cardiovasc.Pharmacol. 2014 PMID: 24336017

Product Documents for 16673-34-0 NLRP3i

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.