CXCR2/IL-8RB: Small Molecules and Peptides
CXCR2/IL-8RB is a member of the CXC chemokine receptor subfamily. Similar to other chemokine receptors, it is a G protein-coupled receptor (GPCR). Human CXCR2/IL-8RB is 360 amino acids (aa) in length with a predicted molecular weight of 41 kDa. The human protein shares 71% aa sequence identity with the mouse and rat protein. CXCR2/IL-8RB is expressed on neutrophils and activates neutrophil chemotaxis.
Similar to the closely related CXCR1/IL-8RA, CXCR2/IL-8RB binds and mediates CXCL8/IL-8-induced neutrophil activation. It also binds additional CXC chemokine ligands that contain an ELR aa motif. CXCR2/IL-8RB is implicated in neurological and pulmonary inflammatory diseases and injury. As such, it is a therapeutic target of interest in inflammatory disease and cancer.
Products:
4 results for "CXCR2/IL-8RB Small Molecules and Peptides" in Products
4 results for "CXCR2/IL-8RB Small Molecules and Peptides" in Products
CXCR2/IL-8RB: Small Molecules and Peptides
CXCR2/IL-8RB is a member of the CXC chemokine receptor subfamily. Similar to other chemokine receptors, it is a G protein-coupled receptor (GPCR). Human CXCR2/IL-8RB is 360 amino acids (aa) in length with a predicted molecular weight of 41 kDa. The human protein shares 71% aa sequence identity with the mouse and rat protein. CXCR2/IL-8RB is expressed on neutrophils and activates neutrophil chemotaxis.
Similar to the closely related CXCR1/IL-8RA, CXCR2/IL-8RB binds and mediates CXCL8/IL-8-induced neutrophil activation. It also binds additional CXC chemokine ligands that contain an ELR aa motif. CXCR2/IL-8RB is implicated in neurological and pulmonary inflammatory diseases and injury. As such, it is a therapeutic target of interest in inflammatory disease and cancer.
Products:
Potent CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)urea |
| Purity: | ≥98% (HPLC) |
Potent CXCR2 antagonist
| Chemical Name: | 5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one |
| Purity: | ≥98% (HPLC) |
Potent and selective CXCR2 antagonist
| Chemical Name: | N-(2-Bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)urea |
| Purity: | ≥98% (HPLC) |
Potent CXCR2 antagonist
| Chemical Name: | 6-Chloro-3-[[[(2,3-dichlorophenyl)amino]carbonyl]amino]-2-hydroxybenzenesulfonamide |
| Purity: | ≥98% (HPLC) |
