AZ 10397767

Name: AZ 10397767
Brand: Tocris Bioscience
SKU: 5872

Tocris Bioscience, part of Bio-Techne | Catalog # 5872

Citations (6)

COA / SDS

Potent CXCR2 antagonist

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Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Potent CXCR2 antagonist

View all Chemokine CXC Receptor Antagonists »

Product Description

AZ 10397767 is a potent CXCR2 antagonist (IC₅₀ = 1 nM); attenuates oxaliplatin-induced NF-κB activation, increases oxaliplatin cytotoxicity, and potentiates oxaliplatin-induced apoptosis in AIPC cells. Reduces the numbers of neutrophils infiltrating into tumors in both in vitro and in vivo models and delayed tumor growth. Orally bioavailable.

Product Specifications

Molecular Weight

400.88

Formula

C₁₅H₁₄ClFN₄O₂S₂

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

5-[[(3-Chloro-2-fluorophenyl)methyl]thio]-7-[[(1R)-2-hydroxy-1-methylethyl]amino]thiazolo[4,5-d]pyrimidin-2(3H)-one

CAS Number

333742-63-5

PubChem ID

11858154

InChI Key

KHTUORKUWBDRBX-SSDOTTSWSA-N

SMILES

C[C@@H](NC1=C2SC(NC2=NC(SCC3=C(C(Cl)=CC=C3)F)=N1)=O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	40.09	100

Preparing Stock Solutions for AZ 10397767

The following data is based on the product molecular weight 400.88

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.47 mL	24.95 mL
5 mM	0.50 mL	2.49 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Background References

References are publications that support the biological activity of the product.

Walters Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg.Med.Chem.Lett. 2008 PMID: 18240390
Tazzyman Inhibition of neutrophil infiltration into A549 lung tumors in vitro and in vivo using a CXCR2-specific antagonist is associated with reduced tumor growth. Int.J.Cancer 2011 PMID: 21328342
Wilson Chemotherapy-induced CXC-chemokine/CXC-chemokine receptor signaling in metastatic prostate cancer cells confers resistance to oxalip. through potentiation of nuclear factor-kappaB transcription and evasion of apoptosis. J.Pharmacol.Exp.Ther. 2008 PMID: 18780829