Oxaliplatin

Name: Oxaliplatin
Brand: Tocris Bioscience
SKU: 2623
Rating: 5 (2 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 2623

(2)

Citations (77)

COA / SDS

DNA cross-linking antitumor agent

Key Product Details

Description:	DNA cross-linking antitumor agent
Alternative Names:	Eloxatin
Chemical Name:	Oxalato[(1R-trans)-1,2-cyclohexanediamine]platinum(II)
Purity:	≥98% (HPLC)
Molecular Weight:	397.29

View Full Technical Details for Oxaliplatin

Technical Data
Citations / Reviews (2)

Biological Activity for Oxaliplatin

Oxaliplatin is an antitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (Cat. No. 2251) and shows antitumor activity in cell lines with acquired cisplatin resistance.

Technical Data for Oxaliplatin

M. Wt	397.29
Formula	C₈H₁₄N₂O₄Pt
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	61825-94-3
PubChem ID	9887054
InChi Key	ZROHGHOFXNOHSO-BNTLRKBRSA-L
Smiles	[Pt++].[O-]C(=O)C([O-])=O.[H][C@@]1(N)CCCC[C@@]1([H])N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Oxaliplatin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	1.99	5 with gentle warming

Preparing Stock Solutions for Oxaliplatin

The following data is based on the product molecular weight 397.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	50.34 mL	251.71 mL	503.41 mL
0.25 mM	10.07 mL	50.34 mL	100.68 mL
0.5 mM	5.03 mL	25.17 mL	50.34 mL
2.5 mM	1.01 mL	5.03 mL	10.07 mL

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Reconstitution Calculator

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References for Oxaliplatin

References are publications that support the biological activity of the product.

Raymond Cellular and molecular pharmacology of oxalip. Mol.Cancer Ther. 2002 PMID: 12467217
Mani Oxaliplatin: a review of evolving concepts. Cancer Invest. 2002 PMID: 11901545
Culy Oxaliplatin. A review of its pharmacological properties and clinical efficacy in metastatic colorectal cancer and its potential in other malignancies. Drugs 2000 PMID: 11085200