Compounds for Stem Cell Differentiation

Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs

Potent AMPK inhibitor; also BMP type I receptor inhibitor

Selective JNK inhibitor

Potent pan-salt inducible kinases (SIK1, SIK2 and SIK3) inhibitor. Also inhibits Lat-B-induced EP differentiation via nuclear YAP1 accumulation.

Selective ALK2 inhibitor

FGFR1 and -3 inhibitor

5-HT reuptake inhibitor

CK1 inhibitor

Histone deacetylase inhibitor

Dual α9β1/α4β1 integrin inhibitor; preferentially mobilizes HSCs

PDE inhibitor (non-selective)

Potent, reversible EGFR tyrosine kinase inhibitor

Potent inhibitor of Wnt/β-catenin signaling

Highly potent and selective GSK-3 inhibitor

DNA methyltransferase inhibitor

SCD-1 inhibitor

Potent and selective Foxo1 inhibitor; orally bioavailable

Potent pan-JAK inhibitor; induces intermediate mesoderm; cell-permeable

HIF α-subunit inhibitor

Potent GSK3 inhibitor; induces neuronal and CD8(+) T cell differentiation

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells

Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells