Erlotinib Hydrochloride

Name: Erlotinib Hydrochloride
Brand: Tocris Bioscience
SKU: 7194

Tocris Bioscience, part of Bio-Techne | Catalog # 7194

COA / SDS

Potent, reversible EGFR tyrosine kinase inhibitor

Key Product Details

Description:	Potent, reversible EGFR tyrosine kinase inhibitor
Chemical Name:	N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	429.9

View Full Technical Details for Erlotinib Hydrochloride

Technical Data
Citations

Biological Activity for Erlotinib Hydrochloride

Erlotinib hydrochloride is a reversible, potent EGFR tyrosine kinase inhibitor (IC₅₀ = 2 nM); it reduces EGFR autophosphorylation in intact tumor cells (IC₅₀ = 20 nM). Erlotinib is selective for cell lines showing PC-9 and H3255 mutations (IC₅₀ values are 7 and 12 nM, respectively, sparing wild-type and T790 mutant EGFR. Erlotinib shows antiproliferative effects in cancer cell lines in vitro and promotes differentiation of urothelial organoids. Orally bioavailable.

Compound Libraries for Erlotinib Hydrochloride

Erlotinib Hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data for Erlotinib Hydrochloride

M. Wt	429.9
Formula	C₂₂H₂₃N₃O₄.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	183319-69-9
PubChem ID	176871
InChi Key	GTTBEUCJPZQMDZ-UHFFFAOYSA-N
Smiles	Cl.C#CC1=CC=CC(=C1)NC=2N=CN=C3C=C(OCCOC)C(OCCOC)=CC32

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Erlotinib Hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	8.6	20

Preparing Stock Solutions for Erlotinib Hydrochloride

The following data is based on the product molecular weight 429.9.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	11.63 mL	58.15 mL	116.31 mL
1 mM	2.33 mL	11.63 mL	23.26 mL
2 mM	1.16 mL	5.82 mL	11.63 mL
10 mM	0.23 mL	1.16 mL	2.33 mL

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References for Erlotinib Hydrochloride

References are publications that support the biological activity of the product.

Moyer Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997 PMID: 9354447
Santos Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacity. Nat.Commun. 2019 PMID: 31562298