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Bromodomain Inhibitors Products

46 results for "Bromodomain Inhibitors" in Products

46 results for "Bromodomain Inhibitors" in Products

Bromodomain Inhibitors Products

Potent and selective BET bromodomain inhibitor; cell permeable

Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester
Purity: ≥98% (HPLC)
Potent and selective BET bromodomain inhibitor; cell permeable

BET bromodomain inhibitor; orally bioavailable

Alternate Names: Birabresib
Chemical Name: (6S)-4-(4-Chlorophenyl)-N-(4-hydroxyphenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98% (HPLC)
BET bromodomain inhibitor; orally bioavailable

Broad spectrum bromodomain inhibitor

Chemical Name: N-[(6-3-Methanesulfonamido-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]carbamate
Purity: ≥98% (HPLC)
Broad spectrum bromodomain inhibitor

BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

Chemical Name: 7-(3,5-Dimethyl-4-isoxazolyl)-1,3-dihydroxy-8-methoxy-1-[(1R)-1-(2-pyridinyl)ethyl]-2H-imidazo[4,5-c]quinolin-2-one dihydrochloride
Purity: ≥98% (HPLC)
BET bromodomain inhibitor; also promotes differentiation of hiPSCs into megakaryocytes

BET bromodomain inhibitor; arrests cell cycle at G1 phase

Alternate Names: TEN 010
Chemical Name: (6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98% (HPLC)
BET bromodomain inhibitor; arrests cell cycle at G1 phase

Potent and selective ATAD2 bromodomain inhibitor

Chemical Name: (1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one
Purity: ≥98% (HPLC)
Potent and selective ATAD2 bromodomain inhibitor

Potent and selective BRPF bromodomain inhibitor

Chemical Name: 4-Cyano-N-(1,3-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)-2-methoxybenzene-1-sulfonamide
Purity: ≥98% (HPLC)
Potent and selective BRPF bromodomain inhibitor

Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.

Alternate Names: GSK525762A,Molibresib
Chemical Name: (4S)-6-(4-Chlorophenyl)-N-ethyl-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine-4-acetamide
Purity: ≥98% (HPLC)
Potent and high affinity BET bromodomain inhibitor; anti-inflammatory; orally bioavailable.

BET bromodomain inhibitor

Chemical Name: 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide
Purity: ≥98% (HPLC)
BET bromodomain inhibitor

High affinity and selective PCAF bromodomain inhibitor

Chemical Name: (1S, 2S)-N1,N1-Dimethyl-N2-(3-methyl-1,2,4-triazolo[3,4-a]phthalazin-6-yl)-1-phenylpropane-1,2-diamine dihydrochloride
Purity: ≥98% (HPLC)
High affinity and selective PCAF bromodomain inhibitor

Selective p300/CBP bromodomain inhibitor

Chemical Name: (6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone
Purity: ≥98% (HPLC)
Selective p300/CBP bromodomain inhibitor

Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor

Chemical Name: 1,1-Dimethylethyl 4-[3-amino-6-(2-hydroxyphenyl)-4-pyridazinyl]-1-piperazinecarboxylate bromodomains
Purity: ≥98% (HPLC)
Potent and selective SMARCA2/4 and PB1(bromo 5)-selective SWI/SNF bromodomain inhibitor

BET bromodomain Degrader (PROTAC®); also potent Hedgehog pathway inhibitor

Chemical Name: 2-Methoxyethyl 4-(3-((1-(6-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)hexyl)-1H-1,2,3-triazol-4-yl)methoxy)phenyl)-7-(2-methoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
Purity: ≥98% (HPLC)
BET bromodomain Degrader; also potent Hedgehog pathway inhibitor

(+)-JQ1 based Degrader (PROTAC®) that preferentially degrades BRD4

Chemical Name: (2S,4R)-1-((S)-2-(tert-butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecanoyl)- 4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
Application of MZ 1 in HeLa Cells
(2)

CECR2 and BPTF/FALZ inhibitor

Chemical Name: N-[(3-(1H)-Pyrazol-1-yl)propyl)-6-(4-(3-(dimethylamino)propoxy)phenyl)-2-(methylsulfonyl)pyrimidin-4-amine hydrochloride
Purity: ≥98% (HPLC)
CECR2 and BPTF/FALZ inhibitor

Potent and selective BRD9 inhibitor

Chemical Name: 5-Ethyl-4,5-dihydro-4-oxo-N-(tetrahydro-1,1-dioxido-2H-thiopyran-4-yl)-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide
Purity: ≥98% (HPLC)
Potent and selective BRD9 inhibitor

Selective BRD7 and BRD9 inhibitor

Chemical Name: N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Purity: ≥98% (HPLC)
Selective BRD7 and BRD9 inhibitor

Potent and selective SMARCA4/2 inhibitor

Chemical Name: (S)-1-(Methylsulfonyl)-N-[4-(methylthio)-1-oxo-1-[[4-[3-(pyridin-4-yl)phenyl]thiazol-2-yl]amino]butan-2-yl]-1H-pyrrole-3-carboxamide
Purity: ≥95% (HPLC)
Potent and selective SMARCA4/2 inhibitor

Potent and selective pan-BD2 inhibitor; orally bioavailable

Alternate Names: GSK046
Chemical Name: 4-(Acetylamino)-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide
Purity: ≥98% (HPLC)
Potent and selective pan-BD2 inhibitor; orally bioavailable

Potent and selective BRD9 and BRD7 inhibitor; orally active

Chemical Name: 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one
Purity: ≥98% (HPLC)
Potent and selective BRD9 and BRD7 inhibitor; orally active

Potent CBP/p300 BRD inhibitor

Chemical Name: 2-[2-(3-Chloro-4-methoxyphenyl)ethyl]-5-(dimethyl-1,2-oxazol-4-yl)-1-[(2S)-2-(morpholin-4-yl)propyl]-1H-1,3-benzodiazole
Purity: ≥98% (HPLC)
Potent CBP/p300 BRD inhibitor

Selective MLLT1/3 inhibitor

Chemical Name: N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Purity: ≥98% (HPLC)
Selective MLLT1/3 inhibitor

Potent and selective CECR2 inhibitor

Chemical Name: N-Cyclopropyl-2-(propylsulfonyl)-6-(1-(2,2,6,6-tetramethylpiperidin-4-yl)-1H-indol-5-yl)pyrimidin-4-amine
Purity: ≥98% (HPLC)
Potent and selective CECR2 inhibitor

(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

Chemical Name: (6S)-4-(4-Chlorophenyl)-N-[4-[[2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetyl]amino]butyl]-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetamide
Purity: ≥98% (HPLC)
(+)-JQ1 based Degrader (PROTAC®) targeting BET bromodomains, active in vivo

(+)-JQ1 based PROTAC® with selectivity for BRD4

Chemical Name: (2S,4R)-1-(2R)-2-Acetamido-3-[[6-[2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamido]hexyl]thio]-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methylthiazol-5-yl)benzyl)pyrrolidinine-2-carboxamide
Purity: ≥98% (HPLC)
(+)-JQ1 based PROTAC® with selectivity for BRD4
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