AZ 13824374
Tocris Bioscience, part of Bio-Techne | Catalog # 7757
Potent and selective ATAD2 bromodomain inhibitor
Key Product Details
Description
Potent and selective ATAD2 bromodomain inhibitor
Product Description
AZ 13824374 is a potent and selective inhibitor of ATPase family AAA domain-containing protein 2 (ATAD2) bromodomain (pIC50 values are 6.2 and 8.2 in NanoBRET assay and FRET assay, respectively). It is >100-fold selective over a range of epigenetic targets from ROMOscan panel (DiscoveRx Corp.). AZ 13824374 shows cellular target engagement (cellular inhibition pIC50 = 6.9) and antiproliferative activity in a range of breast cancer cell lines.Licensing Information
Sold with the permission of AstraZeneca UK Ltd.Product Specifications
Molecular Weight
562.69
Formula
C30H39FN8O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(1R,2R,5S)-11-(8-((1-(2-Fluoro-2-methylpropyl)piperidin-4-yl)amino)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazine-6-carbonyl)-2-isopropyl-2,3,5,6-tetrahydro-1,5-epiminobenzo[d]azocin-4(1H)-one
CAS Number
3040082-19-4
PubChem ID
162422438
InChI Key
NGXAMXNWIHBLBN-JIMJEQGWSA-N
SMILES
CC(C)[C@H]1NC([C@@H]2CC3=C([C@H]1N2C(C4=NN5C(C)=NN=C5C(NC6CCN(CC6)CC(F)(C)C)=C4)=O)C=CC=C3)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 56.27 | 100 | |
| Ethanol | 56.27 | 100 |
Preparing Stock Solutions
for AZ 13824374
The following data is based on the product molecular weight 562.69
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.78 mL | 8.89 mL | 17.77 mL |
| 5 mM | 0.36 mL | 1.78 mL | 3.55 mL |
| 10 mM | 0.18 mL | 0.89 mL | 1.78 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Winter-Holt Discovery of a potent and selective ATAD2 bromodomain inhibitor with antiproliferative activity in breast cancer models. J.Med.Chem. 2022 PMID: 35133824
Product Specific Notices for AZ 13824374
For research use only
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