NVS MLLT-1

Name: NVS MLLT-1
Brand: Tocris Bioscience
SKU: 7482

Tocris Bioscience, part of Bio-Techne | Catalog # 7482

COA / SDS

Selective MLLT1/3 inhibitor

Key Product Details

Description:	Selective MLLT1/3 inhibitor
Chemical Name:	N-[2-[[(2S)-2-Methyl-1-pyrrolidinyl]methyl]-1H-benzimidazol-6-yl]-6-isoquinolinecarboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	385.47

View Full Technical Details for NVS MLLT-1

Technical Data
Citations

Biological Activity for NVS MLLT-1

NVS MLLT-1 is a selective inhibitor of YEATS domain of MLLT1 and MLLT3 (IC₅₀values are 150 and 254 nM for MLLT1 and MLLT3, respectively). It shows selectivity for YEATS2/4 domains and over all bromodomains (CERC2 IC₅₀ > 40 μM).

Licensing Information

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the NVS MLLT-1 probe summary on the SGC website.

Compound Libraries for NVS MLLT-1

NVS MLLT-1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NVS MLLT-1

M. Wt	385.47
Formula	C₂₃H₂₃N₅O
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	2561471-13-2
PubChem ID	155925910
InChi Key	ZRTFTZCKJUNZIU-HNNXBMFYSA-N
Smiles	C[C@H]1CCCN1CC2=NC3=CC=C(C=C3N2)NC(C4=CC5=C(C=NC=C5)C=C4)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NVS MLLT-1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	38.55	100
	ethanol	19.27	50

Preparing Stock Solutions for NVS MLLT-1

The following data is based on the product molecular weight 385.47.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.59 mL	12.97 mL	25.94 mL
5 mM	0.52 mL	2.59 mL	5.19 mL
10 mM	0.26 mL	1.30 mL	2.59 mL
50 mM	0.05 mL	0.26 mL	0.52 mL

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References for NVS MLLT-1

References are publications that support the biological activity of the product.

Ni Structure and inhibitor binding characterization of oncogenic MLLT1 mutants. ACS Chem.Biol. 2021 PMID: 33749253