10 results for "Androgen R/NR3C4 Small Molecules and Peptides" in Products
Androgen R/NR3C4: Small Molecules and Peptides
Human Androgen Receptor (AR; NR3C4) is a 110 kDa member of the NR3 subfamily of the nuclear hormone receptor family. Androgen receptors are expressed by androgen-sensitive tissue (bone, prostate, testis) and exist as both ahomodimers and a heterodime in a complex with the glucocorticoid receptor. Multiple forms of the androgen receptor are known to exist. The 110 kDa 'B' form is 919 amino acids in length. Phosphorylation increases its molecular weight to 112 kDa and 114 kDa. A five amino acid ...
Potent and selective androgen receptor Degrader (PROTAC®)
| Chemical Name: | (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
Steroidal androgen receptor agonist
| Chemical Name: | (4aα,4bβ,6aα,7α,9aβ,9bα,11aβ)-N-(2-Chlorophenyl)-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1,4,6a-trimethyl-2-oxo-1H-indeno[5,4-f]quinoline-7-carboxamide |
| Purity: | ≥98% (HPLC) |
Progesterone and glucocorticoid receptor antagonist
| Alternate Names: | RU 486,RU 38486 |
| Chemical Name: | (11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one |
| Purity: | ≥98% (HPLC) |
Non-steroidal androgen receptor antagonist
| Alternate Names: | SCH 13521 |
| Chemical Name: | 2-Methyl-N-(4-nitro-3-[trifluoromethyl]phenyl)propanamide |
| Purity: | ≥98% (HPLC) |
Mineralocorticoid receptor antagonist
| Alternate Names: | SC 9420,Aldactone |
| Chemical Name: | (7α,17α)-7-(Acetylthio)-17-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone |
| Purity: | ≥98% (HPLC) |
CYP17 inhibitor; also androgen receptor antagonist
| Alternate Names: | TOK-001,VN/124-1 |
| Chemical Name: | (3β)-17-(1H-Benzimidazol-1-yl)androsta-5,16-dien-3-ol |
| Purity: | ≥98% (HPLC) |
Selective androgen receptor modulator (SARM)
| Chemical Name: | (1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective AR and AR L702H Degrader, orally bioavailable
| Chemical Name: | 4-[4-[4-[4-[[4-[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-7-methoxy-1-oxo-1H-isoindol-5-yl]-1-piperazinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-3-fluoro-2-(trifluoromethyl)benzonitrile |
| Purity: | ≥98% (HPLC) |
Selective p300/CBP bromodomain inhibitor
| Chemical Name: | (6S)-1-(3,4-Difluorophenyl)-6-[5-(3,5-dimethyl-4-isoxazolyl)-1-(trans-4-methoxycyclohexyl)-1H-benzimidazol-2-yl]-2-piperidinone |
| Purity: | ≥98% (HPLC) |
Negative control for ARCC 4 (Cat. No. 7254)
| Chemical Name: | (2S,4S)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% (HPLC) |
