TFM-4AS-1
Tocris Bioscience, part of Bio-Techne | Catalog # 3813
Selective androgen receptor modulator (SARM)
Key Product Details
Description
Selective androgen receptor modulator (SARM)
Product Description
TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM). Steroidal compound. Exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Inhibits 5α-reductase type I and II (IC50 values are 2 and 3 nM respectively).Product Specifications
Molecular Weight
474.56
Formula
C27H33F3N2O2
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(1S,3aS,3bS,5aR,9aR,9bS,11aS)-6,9a,11a-Trimethyl-7-oxo-N-[2-(trifluoromethyl)phenyl]-2,3,3a,3b,4,5,5a,9b,10,11-decahydro-1H-indeno[5,4-f]quinoline-1-carboxamide
CAS Number
188589-61-9
PubChem ID
10277123
InChI Key
YFBLEKKYWFJKBP-JZFZSVFHSA-N
SMILES
O=C1C=C[C@@]2(C)[C@](CC[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@H]4[C@@](NC5=C(C(F)(F)F)C=CC=C5)=O)([H])N1C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.75 | 10 | |
| Ethanol | 4.75 | 10 |
Preparing Stock Solutions
for TFM-4AS-1
The following data is based on the product molecular weight 474.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.07 mL | 105.36 mL | 210.72 mL |
| 0.5 mM | 4.21 mL | 21.07 mL | 42.14 mL |
| 1 mM | 2.11 mL | 10.54 mL | 21.07 mL |
| 5 mM | 0.42 mL | 2.11 mL | 4.21 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Schmidt Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands. J.Biol.Chem. 2009 PMID: 19846549
Product Specific Notices for TFM-4AS-1
For research use only
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