Mifepristone

Tocris Bioscience, part of Bio-Techne | Catalog # 1479

Progesterone and glucocorticoid receptor antagonist
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Key Product Details

Description

Progesterone and glucocorticoid receptor antagonist

Alternative Names

RU 486,RU 38486

View all Progesterone Receptor Antagonists »

Product Description

Mifepristone is a selective antagonist at progesterone (PR) and glucocorticoid (GR) receptors in vitro and in vivo. Is a silent antagonist at PR and has a higher affinity than progesterone. Has higher affinity for GR than dexamethasone (Cat. No. 1126).

Product Specifications

Molecular Weight

429.60

Formula

C29H35NO2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(11β,17β)-11-[4-(Dimethylamino)phenyl]-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one

CAS Number

84371-65-3

PubChem ID

55245

InChI Key

VKHAHZOOUSRJNA-GCNJZUOMSA-N

SMILES

[H][C@@]23CCC1=CC(CCC1=C2[C@@H]([C@]5=CC=C(N(C)C)C=C5)C[C@@]4(C)[C@]([H])3CC[C@@](C#CC)4O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.96 100
Ethanol 21.48 50 with gentle warming

Preparing Stock Solutions for Mifepristone

The following data is based on the product molecular weight 429.60

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.64 mL 23.28 mL
5 mM 0.47 mL 2.33 mL 4.66 mL
10 mM 0.23 mL 1.16 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for Mifepristone

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Mifepristone

For research use only

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