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18 results for "alpha-2A Adrenergic R/ADRA2A Small Molecules and Peptides" in Products

alpha-2A Adrenergic R/ADRA2A: Small Molecules and Peptides

Alpha-2-adrenergic receptors, including ADRA2A, are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both ADRA2A and ADRA2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The ADRA2A subtype inhibited transmitter release at high stimulation frequencies, whereas the ADRA2C subtype modulated neurotransmission at lower levels of nerve activity.

α2A agonist

Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Purity: ≥98% (HPLC)
α2A agonist

Selective α2 antagonist

Chemical Name: 17α-Hydroxyyohimban-16α-carboxylic acid methyl ester hydrochloride
Purity: ≥98% (HPLC)
Selective α2 antagonist

α2 agonist. Also I1 ligand

Chemical Name: 2-[(2,6-Dichlorophenyl)amino-2-imidazoline hydrochloride
Purity: ≥98% (HPLC)
α2 agonist. Also I1 ligand

Potent and selective α2 antagonist

Chemical Name: 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride
Purity: ≥98% (HPLC)
Potent and selective α2 antagonist

α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline tartrate
Purity: ≥98% (HPLC)
α2 agonist. Water-soluble form of UK 14,304 (Cat. No. 0425)

Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)

Alternate Names: d-Medetomidine hydrochloride
Chemical Name: 4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity: ≥98%
Potent, highly selective α2 agonist. Active isomer of medetomidine (Cat. No. 5160)

α2 agonist

Chemical Name: 5-Bromo-6-(2-imidazolin-2-ylamino)quinoxaline
α2 agonist

Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

Alternate Names: Org 3770,6-Azamianserin
Chemical Name: 1,2,3,4,10,14b-Hexahydro-2-methylpyrazino[2,1-a]pyrido[2,3-c][2]benzazepine
Purity: ≥98% (HPLC)
Potent 5-HT2 antagonist; also 5-HT3, H1 and α2 antagonist; antidepressant

Potent and non-selective β antagonist; also potent α1 antagonist

Alternate Names: BM 14190
Chemical Name: 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol
Purity: ≥98% (HPLC)
Potent and non-selective β antagonist; also potent α1 antagonist

Selective α2 antagonist

Chemical Name: 5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Selective α2 antagonist

Selective α2A antagonist

Chemical Name: 2-[(4,5-Dihydro-1H-imidazol-2-yl)methyl]-2,3-dihydro-1-methyl-1H-isoindole maleate
Purity: ≥98% (HPLC)
Selective α2A antagonist

Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent

Chemical Name: (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole maleate
Purity: ≥98% (HPLC)
Non-selective 5-HT, dopamine, adrenalin and histamine receptor antagonist; antipsychotic agent

Potent and selective adrenergic α2B antagonist

Chemical Name: 1-[2-[[[3-(3,5-Dimethyl-4-isoxazolyl)imidazo[1,2-a]pyridin-7-yl]carbonyl]amino]ethyl]-4-(methylamino)pyridinium chloride
Purity: ≥98% (HPLC)
Potent and selective adrenergic α2B antagonist

Selective α2 agonist

Alternate Names: Azepexole
Chemical Name: 6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride
Purity: ≥98% (HPLC)
Selective α2 agonist

Potent and highly selective α2 agonist

Chemical Name: 4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Potent and highly selective α2 agonist

Potent, selective α2D antagonist

Chemical Name: 2-(2,3-Dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride
Purity: ≥98% (HPLC)
Potent, selective α2D antagonist

5-HT1A antagonist

Chemical Name: 1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Purity: ≥98% (HPLC)
5-HT1A antagonist

α2 agonist

Chemical Name: 5-(Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
Purity: ≥98% (HPLC)
α2 agonist
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