Remdesivir
Tocris Bioscience, part of Bio-Techne | Catalog # 7226
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
Key Product Details
Description
Viral RNA-dependent RNA polymerase (RdRP) inhibitor; broad spectrum antiviral nucleotide prodrug
Alternative Names
GS-5734
Product Description
Remdesivir is a viral RNA-dependent RNA polymerase inhibitor (RdRp) and broad spectrum antiviral nucleotide prodrug. Metabolized to active form, GS 441524 (Cat. No. 7227). Exhibits activity against a range of RNA viruses in vitro (EC50 values are 0.019, 0.07, 0.07 - 0.34, 0.086 - 0.14, and 23.15 μM against RSV, SARS-CoV, MERS-CoV, EBOV and SARS-CoV-2, respectively). Exhibits antiviral efficacy in animal models of MERS-CoV and EBOV infection.Product Specifications
Molecular Weight
602.58
Formula
C27H35N6O8P
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-Ethylbutyl (2S)-2-[[(S)-[[(2R,3S,4R,5R)-5-(4-aminopyrrolo(2,1-f)(1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy]phenoxyphosphoryl]amino]propanoate
CAS Number
1809249-37-3
PubChem ID
121304016
InChI Key
RWWYLEGWBNMMLJ-YSOARWBDSA-N
SMILES
CCC(COC([C@@H](N[P@](OC[C@H]1O[C@]([C@@H]([C@@H]1O)O)(C2=CC=C3N2N=CN=C3N)C#N)(OC4=CC=CC=C4)=O)C)=O)CC
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 60.26 | 100 | |
| Ethanol | 12.05 | 20 |
Preparing Stock Solutions
for Remdesivir
The following data is based on the product molecular weight 602.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.66 mL | 8.30 mL | 16.60 mL |
| 5 mM | 0.33 mL | 1.66 mL | 3.32 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.66 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Warren Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature 2016 PMID: 26934220
- Choy Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2replication in vitro. Antiviral Res. 2020 PMID: 32251767
- Sheahan Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat.Commun. 2020 PMID: 31924756
Product Specific Notices for Remdesivir
For research use only
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