GS 441524

Product Description

GS 441524 is a viral RNA-dependent RNA polymerase (RdRp) inhibitor and broad spectrum antiviral nucleotide; active metabolite of Remdesivir (Cat. No. 7226). Competes with natural nucleoside triphosphates, blocking viral RNA synthesis. Exhibits antiviral activity against viruses from Coronaviridae family including SARS-CoV-2 in vitro, and SARS-CoV and feline infectious peritonitis virus (FIPV) in vitro and in vivo. Inhibits SARS-CoV and MERS-CoV- infected HAE cultures (EC₅₀ values are 0.18 and 0.86 μM, respectively) and inhibits murine hepatitis virus (MHV) (EC₅₀ = 1.1 μM).

Solubility

Preparing Stock Solutions for GS 441524

The following data is based on the product molecular weight 291.27

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.43 mL	17.17 mL	34.33 mL
5 mM	0.69 mL	3.43 mL	6.87 mL
10 mM	0.34 mL	1.72 mL	3.43 mL
50 mM	0.07 mL	0.34 mL	0.69 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Cho Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides Bioorg.Med.Chem.Lett. 2012 PMID: 22446091
• Agostini Coronavirus susceptibility to the antiviral Remdesivir (GS-5734) is mediated by the viral polymerase and the proofreading exoribonuclease mBio. 2018 PMID: 29511076