Ceefourin 1

Tocris Bioscience, part of Bio-Techne | Catalog # 5867

Selective MRP4 inhibitor
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Key Product Details

Description

Selective MRP4 inhibitor

View all Multidrug Transporter Inhibitors »

Product Description

Ceefourin 1 is a selective MRP (multidrug resistance-associated protein) 4 inhibitor (IC50 = 2.6 μM). Selective for MRP4 over P-gp, MRP1 and ABCG2. Sensitizes MRP4 over-expressing cells to SN 38 (Cat. No. 2684). Ceefourin 1 inhibits cAMP efflux from acute myeloid leukemia cells (AML) and promotes apoptosis in combination with Histamine (Cat. No. 3545).

Product Specifications

Molecular Weight

294.42

Formula

C11H10N4S3

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[(2-Benzothiazolylthio)methyl]-2,4-dihydro-4-methyl-3H-1,2,4-triazole-3-thione

CAS Number

315702-40-0

PubChem ID

704306

InChI Key

KVNBVHCJAUXKPJ-UHFFFAOYSA-N

SMILES

CN1C(NN=C1CSC2=NC3=CC=CC=C3S2)=S

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.44 100

Preparing Stock Solutions for Ceefourin 1

The following data is based on the product molecular weight 294.42

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.40 mL 16.98 mL 33.97 mL
5 mM 0.68 mL 3.40 mL 6.79 mL
10 mM 0.34 mL 1.70 mL 3.40 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Ceefourin 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Ceefourin 1

For research use only

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