Histamine dihydrochloride

Name: Histamine dihydrochloride
Brand: Tocris Bioscience
SKU: 3545
Rating: 4 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3545

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Citations (41)

COA / SDS

Endogenous histamine receptor agonist

Key Product Details

Description:	Endogenous histamine receptor agonist
Chemical Name:	2-(4-Imidazolyl)ethylamine dihydrochloride
Molecular Weight:	184.07

View Full Technical Details for Histamine dihydrochloride

Technical Data
Citations / Reviews (1)

Biological Activity for Histamine dihydrochloride

Histamine dihydrochloride is an endogenous agonist at histamine receptors (H_1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.

Compound Libraries for Histamine dihydrochloride

Histamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Histamine dihydrochloride

M. Wt	184.07
Formula	C₅H₉N₃.2HCl
Storage	Desiccate at RT
CAS Number	56-92-8
PubChem ID	5818
InChi Key	PPZMYIBUHIPZOS-UHFFFAOYSA-N
Smiles	NCCC1=CNC=N1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Histamine dihydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	18.41	100
	DMSO	18.41	100

Preparing Stock Solutions for Histamine dihydrochloride

The following data is based on the product molecular weight 184.07.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.43 mL	27.16 mL	54.33 mL
5 mM	1.09 mL	5.43 mL	10.87 mL
10 mM	0.54 mL	2.72 mL	5.43 mL
50 mM	0.11 mL	0.54 mL	1.09 mL

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Reconstitution Calculator

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References for Histamine dihydrochloride

References are publications that support the biological activity of the product.

Thurmond The role of histamine H₁ and H₄ receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 2008 PMID: 18172439
Maintz and Novak Histamine and histamine intolerance. Am.J.Clin.Nutr. 2007 PMID: 17490952
Hill International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 1997 PMID: 9311023