SN 38

Name: SN 38
Brand: Tocris Bioscience
SKU: 2684

Tocris Bioscience, part of Bio-Techne | Catalog # 2684

Citations (79)

COA / SDS

DNA topoisomerase I inhibitor; antitumor

Key Product Details

Description:	DNA topoisomerase I inhibitor; antitumor
Alternative Names:	7-Ethyl-10-hydroxycamptothecin
Chemical Name:	(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Purity:	≥98% (HPLC)
Molecular Weight:	392.4

View Full Technical Details for SN 38

Technical Data
Citations

Biological Activity for SN 38

SN 38 is an active metabolite of CPT-11 (Cat. No. 2688) that inhibits DNA topoisomerase I (IC₅₀ values are 0.74 and 1.9 μM in P388 and Ehrlich cells respectively). Inhibits DNA and RNA synthesis (IC₅₀ values are 0.077 and 1.3 μM respectively) but does not affect protein synthesis. Displays potent antitumor activity against a range of human tumor cell lines (IC₅₀ values are 3.3, 13, 19 and 22 nM for HCT-116, BEL-7402, HL60 and HELA cells respectively).

Compound Libraries for SN 38

SN 38 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SN 38

M. Wt	392.4
Formula	C₂₂H₂₀N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	86639-52-3
PubChem ID	104842
InChi Key	FJHBVJOVLFPMQE-QFIPXVFZSA-N
Smiles	OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for SN 38

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	19.62	50

Preparing Stock Solutions for SN 38

The following data is based on the product molecular weight 392.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.10 mL	25.48 mL	50.97 mL
2.5 mM	1.02 mL	5.10 mL	10.19 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
25 mM	0.10 mL	0.51 mL	1.02 mL

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References for SN 38

References are publications that support the biological activity of the product.

Gao Synthesis and antitumor activity of the hexacyclic camptothecin derivatives. Bioorg.Med.Chem.Lett. 2005 PMID: 15913996
Koizumi Novel SN-38-incorporating ploymeric micelles, NK012, eradicate vascular endothelial growth factor-Secr.g bulky tumors. Cancer Res. 2006 PMID: 17047068
Kawato Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11. Cancer Res. 1991 PMID: 1651156