CPT 11

Name: CPT 11
Brand: Tocris Bioscience
SKU: 2688

Tocris Bioscience, part of Bio-Techne | Catalog # 2688

Citations (12)

COA / SDS

DNA topoisomerase I inhibitor; antitumor

Key Product Details

Description:	DNA topoisomerase I inhibitor; antitumor
Alternative Names:	Irinotecan,Camptothecin 11
Chemical Name:	(4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylic acid ester hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	623.14

View Full Technical Details for CPT 11

Technical Data
Citations

Biological Activity for CPT 11

CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Active metabolite available (SN 38, Cat. No. 2684).

Compound Libraries for CPT 11

CPT 11 is also offered as part of the Tocriscreen 2.0 Max, Tocriscreen Antiviral Library and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for CPT 11

M. Wt	623.14
Formula	C₃₃H₃₈N₄O₆.HCl
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	100286-90-6
PubChem ID	74990
InChi Key	GURKHSYORGJETM-WAQYZQTGSA-N
Smiles	CCC2=C4C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)=NC1=CC=C(OC(N6CCC(N7CCCCC7)CC6)=O)C=C12.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for CPT 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	3.12	5 with gentle warming
	DMSO	62.31	100

Preparing Stock Solutions for CPT 11

The following data is based on the product molecular weight 623.14.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.60 mL	8.02 mL	16.05 mL
5 mM	0.32 mL	1.60 mL	3.21 mL
10 mM	0.16 mL	0.80 mL	1.60 mL
50 mM	0.03 mL	0.16 mL	0.32 mL

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References for CPT 11

References are publications that support the biological activity of the product.

Vassal Therapeutic activity of CPT-11, a DNA topoisomerase I inhibitor against peripheral primitive neuroectodermal tumour and neuroblastoma xenografts. Br.J.Cancer. 1996 PMID: 8761367
Morton Activation and antitumour activity of CPT-11 in plasma esterase-deficient mice. Can.Chemother.Pharmacol. 2005 PMID: 15918039
Kawato Inhibitory activity of camptothecin derivatives against acetylcholinesterase in dogs and their binding activity to acetylcholine receptors in rats. J.Pharm.Pharmacol. 1993 PMID: 8099964