Bromocriptine mesylate

Tocris Bioscience, part of Bio-Techne | Catalog # 0427

D2-like agonist (D2>D3>D4)
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Key Product Details

Description

D2-like agonist (D2>D3>D4)

View all Non-selective Dopamine Receptor Agonists »

Product Description

Bromocriptine mesylate is a selective D3 and D2 dopamine receptor agonist (Ki values are ~ 5 nM and ~ 8 nM respectively). Activates both isoforms of D2 receptor (EC50 values are 0.10-0.12 nM and 4.4 nM for D2L and D2S receptors, respectively. Bromocriptine shows anti-Aβ effects that are increased in combination with Cromolyn (Cat. No. 6424) and Topiramate (Cat. No. 3620). Also lowers glucose and increases insulin sensitivity in vivo.

Product Specifications

Molecular Weight

750.70

Formula

C32H40BrN5O5.CH3SO3H

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(5'a)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione mesylate

CAS Number

22260-51-1

PubChem ID

31100

InChI Key

NOJMTMIRQRDZMT-GSPXQYRGSA-N

SMILES

[H][C@]4([C@@](N[C@]([C@H](C)C)5C(N([C@@]([H])(CC(C)C)C(N(CCC7)[C@@]76[H])=O)[C@@]6(O)O5)=O)=O)CN([C@](C3=C4)([H])CC1=C(Br)NC2=C1C3=CC=C2)C.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 75.07 100

Preparing Stock Solutions for Bromocriptine mesylate

The following data is based on the product molecular weight 750.70

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.66 mL 13.32 mL
5 mM 0.27 mL 1.33 mL 2.66 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Bromocriptine mesylate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Bromocriptine mesylate

For research use only

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