Vanilloid R-like 3/TRPV3: Small Molecules and Peptides
Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70 kDa member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22°C and 40°C.
Human VRL-3 is 790 amino acids (aa) in length. VRL-3 is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa # 214 - 369). There is one VRL-3 alternate splice form that shows a 6 aa substituton for the C-terminal 31 amino acids. Over amino acids 6 - 15, human VRL-3 shares 90% aa sequence identity with mouse and canine VRL-3.
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Vanilloid R-like 3/TRPV3: Small Molecules and Peptides
Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70 kDa member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22°C and 40°C.
Human VRL-3 is 790 amino acids (aa) in length. VRL-3 is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa # 214 - 369). There is one VRL-3 alternate splice form that shows a 6 aa substituton for the C-terminal 31 amino acids. Over amino acids 6 - 15, human VRL-3 shares 90% aa sequence identity with mouse and canine VRL-3.
Selective TRPV3 antagonist; brain penetrant
| Chemical Name: | (αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol |
| Purity: | ≥98% (HPLC) |
