159 results for "TIM-3" in Products
TIM-3 Products
TIM-3 (T cell immunoglobulin and mucin domain-3), also known as HAVCR2 is an immunosuppressive protein that enhances tolerance and inhibits anti-tumor immunity. It is upregulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). TIM-3 ligation by Galectin-9 attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. Dendritic cell-expressed TIM-3 dampens inflammation by enabling the phagocytosis of apoptotic cells and the cross-presentation of apoptotic cell antigens. TIM-3 also binds the alarmin HMGB1, thereby preventing the activation of TLRs in response to released tumor cell DNA.
Clone 344823 was used by HLDA to establish CD designation
Simple Plex Human TIM-3 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer. Sample type indicated with PS (Plasma/Serum).
Simple Plex cartridges are custom built to fit your needs. Choose from over 350 assays spanning human, mouse, rat, and non-human primate. Just select your sample type, cartridge size (16, 32, or 72 samples), and add up to 8 analytes per cartridge.
Contains 4 membranes - each spotted in duplicate with 105 different cytokine antibodies
Clone 344823 was used by HLDA to establish CD designation
Clone 344823 was used by HLDA to establish CD designation
Recombinant Monoclonal Antibody.
Clone 344823 was used by HLDA to establish CD designation
Recombinant Monoclonal Antibody
Clone 344823 was used by HLDA to establish CD designation
Recombinant Monoclonal Antibody.
