Skp2: Small Molecules and Peptides
SKP2 (S-phase kinase-associated protein 2) is a 45-47 kDa cyclin A- and CDK2-associated phosphoprotein within the FBXL (F-box/LRR) family of ubiquitin ligases, designated FBXL1. As a component of the SCF (SKP1-Cul1-F-box) complex, SKP2 phosphorylation is required for degradation of CDK inhibitors such as p27/Kip1 and progression from G1 to S phases of the cell cycle. Deregulation in cancer promotes cell cycle progression and cancer growth.
2 results for "Skp2 Small Molecules and Peptides" in Products
2 results for "Skp2 Small Molecules and Peptides" in Products
Skp2: Small Molecules and Peptides
SKP2 (S-phase kinase-associated protein 2) is a 45-47 kDa cyclin A- and CDK2-associated phosphoprotein within the FBXL (F-box/LRR) family of ubiquitin ligases, designated FBXL1. As a component of the SCF (SKP1-Cul1-F-box) complex, SKP2 phosphorylation is required for degradation of CDK inhibitors such as p27/Kip1 and progression from G1 to S phases of the cell cycle. Deregulation in cancer promotes cell cycle progression and cancer growth.
Selective Skp2 inhibitor; suppresses E3 ligase activity
| Chemical Name: | 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one |
| Purity: | ≥98% (HPLC) |
SKP2 (S-phase kinase-associated protein 2) inhibitor; upregulates p27 and arrests cell cycle in G1 phase
| Chemical Name: | N-(4-Butyl-2-methylphenyl)acetamide |
| Purity: | ≥98% (HPLC) |
