Protocadherin alpha 1: Proteins and Enzymes

Protocadherin alpha 1 (PCDH alpha 1) is a group A member of the Protocadherin family of molecules. It is expressed in synaptic membranes of neurons, forms obligate Ca²⁺-independent complexes with various PCDH-gamma family members and demonstrates heterophilic binding activity towards beta1 integrins.

Human PCDH alpha 1 is 921 amino acids (aa) in length. It is a type I transmembrane glycoprotein that contains a 668 aa extracellular domain (ECD) plus a 232 aa cytoplasmic region. Both regions ...