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8 results for "Protein Arginine Methyltransferase Inhibitors Small Molecules and Peptides" in Products

Protein Arginine Methyltransferase Inhibitors: Small Molecules and Peptides

Protein Arginine methyltransferases, or PRMTs, are a family of enyzmes that catalyze the transfer of methyl groups from S-adenosylmethionine (SAM) to arginine residues on histones. PRMTs belong to the histone methyltransferase group of enzymes, which also includes lysine methyltransferases. They are also closely related in biological activity to the DNA methyltransferases and are ubiquitously expressed. Histone methylation of arginine residues occurs predominantly on histones H2A, H3 and H4, ...

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Potent and selective PRMT 4 inhibitor

Chemical Name: N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide
Purity: ≥98% (HPLC)
Potent and selective PRMT 4 inhibitor

Potent and selective type I PRMT inhibitor

Chemical Name: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride
Purity: ≥98% (HPLC)
Potent and selective type I PRMT inhibitor

Potent and selective PRMT5 inhibitor

Chemical Name: N-[(2S)-3-(3,4-Dihydro-2(1H)-isoquinolinyl)-2-hydroxypropyl]-6-(3-oxetanylamino)-4-pyrimidinecarboxamide
Purity: ≥98% (HPLC)
Potent and selective PRMT5 inhibitor

Potent and selective PRMT6 allosteric inhibitor

Chemical Name: (R)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
Purity: ≥98% (HPLC)
Potent and selective PRMT6 allosteric inhibitor

Potent and selective allosteric inhibitor of PRMT3

Chemical Name: 1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
Purity: ≥98% (HPLC)
Potent and selective allosteric inhibitor of PRMT3

Negative control of SGC 707 (Cat. No. 5367)

Chemical Name: N-2-Naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea
Purity: ≥98% (HPLC)
Negative control of SGC 707 (Cat. No. 5367)

Selective PRMT5 Degrader (PROTAC®)

Chemical Name: N-((S)-3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-((1-((S)-19-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidine-1-carbonyl)-20,20-dimethyl-17-oxo-3,6,9,12,15-pentaoxa-18-azahenicosanoyl)azetidin-3-yl)amino)pyrimidine-4-carboxamide
Purity: ≥98% (HPLC)
Selective PRMT5 Degrader (PROTAC®)

Negative control for SGC 6870 (Cat. No. 7182)

Chemical Name: (S)-4-(5-Bromothiophene-2-carbonyl)-5-(3,5-dimethylphenyl)-7-methyl-1,3,4,5-tetrahydro-2H-benzo[e][1,4]diazepin-2-one
Purity: ≥98% (HPLC)
Negative control for SGC 6870 (Cat. No. 7182)
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