SGC 707
Tocris Bioscience, part of Bio-Techne | Catalog # 5367
Potent and selective allosteric inhibitor of PRMT3
Key Product Details
Description
Potent and selective allosteric inhibitor of PRMT3
Product Description
SGC 707 is a potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Decreases H4R3me2a levels in HEK293 cells in vitro.Negative control also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website.External Portal Information
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGC 707 is reviewed on the chemical probes website.Product Specifications
Molecular Weight
298.34
Formula
C16H18N4O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1-(Isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl] urea
CAS Number
1687736-54-4
PubChem ID
90642938
InChI Key
DMIDPTCQPIJYFE-UHFFFAOYSA-N
SMILES
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=NC=C3C=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 29.83 | 100 | |
| DMSO | 29.83 | 100 |
Preparing Stock Solutions
for SGC 707
The following data is based on the product molecular weight 298.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.35 mL | 16.76 mL | 33.52 mL |
| 5 mM | 0.67 mL | 3.35 mL | 6.70 mL |
| 10 mM | 0.34 mL | 1.68 mL | 3.35 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.67 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Scheer A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 2019 PMID: 30604761
- Kaniskan A potent, selective and cell-active allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3). Angew.Chem.Int.Ed.Engl 2015 PMID: 25728001
Product Specific Notices for SGC 707
For research use only
Loading...
Loading...