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5 results for "PDGF R alpha" in Products

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PDGF R alpha Products

PDGF R alpha (Platelet-Derived Growth Factor Receptor alpha) is a transmembrane receptor tyrosine kinase that can form homodimers or heterodimers with PDGF R beta when engaged by dimers of the PDGF ligands. PDGF R alpha binds to PDGF-AA, PDGF-AB, and PDGF-CC. It is strongly expressed in oligodendrocyte, lung, skin, and intestinal progenitor cells, at low levels in most mesenchymal cells, and can be induced by inflammation. PDGF R alpha function is important during formation of the cranial and ...

AC 710

Catalog #: 5013

Product Documents

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Potent and selective PDGFR family inhibitor

Chemical Name:

N-[4-[[[[5-(1,1-Dimethethylethyl)-3-isoxazolyl]amino]carbonyl]amino]phenyl]-5-[(1-ethyl-2,2,6,6-tetramethyl-4-piperidinyl)oxy]-2-pyridinecarboxamide

Purity:

≥98%

Imatinib mesylate

Catalog #: 5906

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Potent and selective v-Abl tyrosine kinase inhibitor; also inhibits PDGFR and c-kit

Alternate Names:

Gleevec,CGP 57148B

Chemical Name:

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide methanesulfonate

Purity:

≥98%

CP 673451

Catalog #: 5993

Product Documents

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Potent and selective PDGFR inhibitor

Chemical Name:

1-[2-[5-(2-Methoxyethoxy)-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine

Purity:

≥98%

AP 24534

Catalog #: 4274

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Potent multi-kinase and pan-Bcr-Abl inhibitor

Alternate Names:

Ponatinib

Chemical Name:

3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzamide

Purity:

≥98%

Masitinib

Catalog #: 7705

Product Documents

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Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

Chemical Name:

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide

Purity:

≥98%

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