Masitinib

Tocris Bioscience, part of Bio-Techne | Catalog # 7705

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor
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Key Product Details

Description

Potent colony-stimulating factor 1 receptor (CSF-1R) tyroine kinase inhibitor

View all Additional RTK Inhibitors »

Product Description

Masitinib is a potent inhibitor of the tyrosine kinase receptor colony-stimulating factor 1R (CSF-1R) (IC50 = 90 nM). It is also an NLRP3 inflammasome activator. Masitinib additionally inhibits the proteolytic activity of SARS-CoV-2 main protease (Mpro) and blocks viral replication, as well as acting as a PDGFRα/β inhibitor. In vivo, Masitinib ameliorates cognitive impairment in transgenic mice model of Alzheimer's disease, and slows disease progression in a rat model of amyotrophic lateral sclerosis (ALS). Orally bioavailable.

Product Specifications

Molecular Weight

498.64

Formula

C28H30N6OS

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide

CAS Number

790299-79-5

PubChem ID

10074640

InChI Key

WJEOLQLKVOPQFV-UHFFFAOYSA-N

SMILES

O=C(NC1=CC=C(C(=C1)NC2=NC(=CS2)C=3C=NC=CC3)C)C4=CC=C(C=C4)CN5CCN(C)CC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.86 100
Ethanol 4.99 10

Preparing Stock Solutions for Masitinib

The following data is based on the product molecular weight 498.64

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.03 mL 20.05 mL
5 mM 0.40 mL 2.01 mL 4.01 mL
10 mM 0.20 mL 1.00 mL 2.01 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Masitinib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Masitinib

For research use only

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