PD-1 Products
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells.
When PD-1-expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. The recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
Products:
2140 results for "PD-1" in Products
2140 results for "PD-1" in Products
PD-1 Products
PD-1 (Programmed Death-1 receptor) is a key regulator of the threshold of immune response and peripheral immune tolerance. It is expressed on activated T cells, B cells, monocytes, and dendritic cells and binds to PD-L1 or PD-L2. PD-1 ligation induces co-inhibitory signals in T cells promoting their apoptosis, anergy, and functional exhaustion. Many tumors overexpress PD-L1 to induce this inhibitory signaling pathway in immune cells.
When PD-1-expressing immune cells come into contact with a tumor cell expressing PD-L1, this interaction blocks activation and prevents an immune response. A new class of anti-cancer therapies disrupt these co-inhibitory signals taking the breaks off the host immune system thereby enhancing anti-tumor immunity. The recent success of several antibody therapeutics has spurred great interest in PD-1 and PD-L1 in addition to other co-inhibitory immune checkpoint proteins.
Products:
| Source: | NS0 |
| Accession #: | Q15116.3 |
| Applications: | Bind |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +1 More |
| Sensitivity: | 9.86 pg/mL |
| Assay Range: | 25 - 1,600 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma) |
| Sensitivity: | 3.27 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Cell Lysates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Source: | HEK293 |
| Accession #: | Q15116.3 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q02242 |
| Applications: | Bind |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, CyTOF-ready |
| Source: | NS0 |
| Accession #: | Q02242 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #192106 |
| Applications: | WB |
| Assay Range: | 156 - 10,000 pg/mL |
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #913429 |
| Applications: | WB, Flow, Block, CyTOF-ready |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: PD-1 AntibodyBSA Free [NBP1-77276]](https://resources.bio-techne.com/images/products/PD-1-Antibody-Western-Blot-NBP1-77276-img0005.jpg "Western Blot: PD-1 AntibodyBSA Free [NBP1-77276]")
| Source: | NS0 |
| Accession #: | Q15116.3 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Human IgG4 Kappa Monoclonal Clone #Hu121 |
| Applications: | Flow |
| Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
| Source: | NS0 |
| Accession #: | NP_001100397 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #766104 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Flow, IHC, Block, CyTOF-ready, +2 More |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2705E |
| Applications: | IHC, mIF |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #1026519 |
| Applications: | WB, Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG Monoclonal Clone #1109446 |
| Applications: | WB, IHC, mIF |
