Neuroglycan C/CSPG5: Proteins and Enzymes

Neuroglycan C (NGC; also CSPG5 and CALEB) is a 120-150 kDa type I transmembrane glycoprotein and member of the neuregulin family of proteins. Depending on its expression profile, NGC may be a glycoprotein of 120 kDa, or a chondroitin sulfate (CS) proteoglycan of 150 kDa. Mouse NGC is synthesized as a 566 amino acid (aa) precursor that contains a 30 aa signal sequence, a 393 aa extracellular domain (ECD), a 21 aa transmembrane segment, and a 122 aa cytoplasmic region. The ECD contains one CS ...