7 results for "Monocarboxylate Transporter Inhibitors Small Molecules and Peptides" in Products
Monocarboxylate Transporter Inhibitors: Small Molecules and Peptides
There are 14 members of the solute carrier 16 (SLC16) gene family, four of which (SLC16A1, SLC16A3, SLC16A7 and SLC16A8) encode monocarboxylate transporters; MCT1, MCT4*, MCT2 and MCT3* respectively. MCTs have been shown to transport short-chain monocarboxylates such as L-lactate, ketone bodies and pyruvate across the plasma membrane of mammalian cells. MCTs have 12 transmembrane domains (TMDs) which consist of an intracellular N- and C-terminal and a large intracellular loop between TMDs 6 and ...
Potent and selective monocarboxylate transporter 4 (MCT4) inhibitor
| Chemical Name: | 5-[2-[5-Chloro-2-[[(5-ethoxy-8-quinolinyl)sulfonyl]amino]phenyl]ethynyl]-4-methoxy-2-pyridinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
MCT1 inhibitor; also inhibits hexokinase II
| Chemical Name: | 3-Bromo-2-oxopropanoic acid |
MCT1 and MCT2 inhibitor; inhibits glycolysis in cancer cells
| Chemical Name: | 6-[(3,5-Dimethyl-1H-pyrazol-4-yl)methyl]-5-[[(4S)-4-hydroxy-2-isoxazolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% (HPLC) |
MCT inhibitor; also inhibits mitochondrial pyruvate carrier
| Chemical Name: | 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid |
| Purity: | ≥98% (HPLC) |
Potent MCT1 inhibitor
| Chemical Name: | 2,6-Dihydro-7-[(3-hydroxypropyl)thio]-2-methyl-4-(2-methylpropyl)-6-(1-naphthalenylmethyl)-1H-pyrrolo[3,4-d]pyridazin-1one |
| Purity: | ≥98% (HPLC) |
MCT inhibitor; decreases glycoloysis
| Chemical Name: | 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid |
| Purity: | ≥98% (HPLC) |
MCT1 inhibitor
| Chemical Name: | 5-[[(3R)-3-Hydroxy-1-pyrrolidinyl]carbonyl]-3-methyl-1-(2-methylpropyl)-6-(4-quinolinylmethyl)thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione |
| Purity: | ≥98% (HPLC) |
