UK 5099

Name: UK 5099
Brand: Tocris Bioscience
SKU: 4186

Tocris Bioscience, part of Bio-Techne | Catalog # 4186

Citations (49)

COA / SDS

MCT inhibitor; also inhibits mitochondrial pyruvate carrier

Key Product Details

Description:	MCT inhibitor; also inhibits mitochondrial pyruvate carrier
Chemical Name:	2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	288.3

View Full Technical Details for UK 5099

Technical Data
Citations

Biological Activity for UK 5099

UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for UK 5099

UK 5099 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for UK 5099

M. Wt	288.3
Formula	C₁₈H₁₂N₂O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	56396-35-1
PubChem ID	6438504
InChi Key	BIZNHCWFGNKBBZ-JLHYYAGUSA-N
Smiles	O=C(/C(C#N)=C/C2=CN(C3=CC=CC=C3)C1=CC=CC=C12)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for UK 5099

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	28.83	100

Preparing Stock Solutions for UK 5099

The following data is based on the product molecular weight 288.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.47 mL	17.34 mL	34.69 mL
5 mM	0.69 mL	3.47 mL	6.94 mL
10 mM	0.35 mL	1.73 mL	3.47 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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References for UK 5099

References are publications that support the biological activity of the product.

Hildyard Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae. Biochem.J. 2003 PMID: 12887330
Hinoi A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol.Pharmacol. 2006 PMID: 16766717
Wiemer The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications. Biochem.J. 1995 PMID: 8526859