Keap1: Small Molecules and Peptides
Keap1 is a member of the Kelch family of proteins. Keap1 contains an N-terminal BTB/POZ domain that mediates homodimerization. When dimerized, six Kelch repeats on the extended C-terminus interact with and inactivate Nrf2, a potent transcriptional activator of detoxifying enzymes, providing a homeostatic brake on oxidative stress activity.
2 results for "Keap1 Small Molecules and Peptides" in Products
2 results for "Keap1 Small Molecules and Peptides" in Products
Keap1: Small Molecules and Peptides
Keap1 is a member of the Kelch family of proteins. Keap1 contains an N-terminal BTB/POZ domain that mediates homodimerization. When dimerized, six Kelch repeats on the extended C-terminus interact with and inactivate Nrf2, a potent transcriptional activator of detoxifying enzymes, providing a homeostatic brake on oxidative stress activity.
Covalent allosteric NRF2 inhibitor
| Chemical Name: | 1-[(3R)-3-[3-(4-Amino-1,3,5-triazin-2-yl)-5-chlorophenyl]-4-morpholinyl]-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Nrf2 signaling activator
| Chemical Name: | 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole |
| Purity: | ≥98% (HPLC) |
