IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
745 results for "IL-18/IL-1F4" in Products
745 results for "IL-18/IL-1F4" in Products
IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
| Sensitivity: | 5.15 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva, Urine) |
| Applications: | Simple Plex |
| Assay Range: | 11.7 - 750 pg/mL |
| Applications: | ELISA |
| Sensitivity: | 25 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
| Assay Range: | 46.9 - 3,000 pg/mL |
| Applications: | ELISA |
| Source: | E. coli |
| Accession #: | Q14116 |
| Applications: | BA |
| Sensitivity: | 12.5 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #925008 |
| Applications: | ELISA, CyTOF-ready, ICC, ICFlow |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #125-2H |
| Applications: | IP, Neut |
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #1072G |
| Applications: | ELISA |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Source: | E. coli |
| Accession #: | P70380 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | P97636.1 |
| Applications: | BA |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Applications: | Ctrl, Simple Plex |
| Reactivity: | Human, Rhesus Macaque |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, ELISA, ICC, KO, +1 More |
| Source: | E. coli |
| Accession #: | Q14116.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #159-12B |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #74 |
| Applications: | IP |
| Assay Range: | 62.5 - 4,000 pg/mL |
| Applications: | ELISA |
| Applications: | Simple Plex |