IGFBP-3: Small Molecules and Peptides
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
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IGFBP-3: Small Molecules and Peptides
IGFBP-3 (Insulin-like growth factor binding protein-3) modulates the biological activity of IGF. It circulates in a ternary complex with IGF and the acid-labile subunit (ALS). Proteolysis of IGFBP-3 by tissue plasminogen activator (tPA), a disintegrin and metalloproteases (ADAMs), and prostate specific antigen (PSA) contributes to IGFBP-3 degradation or a reduction in its affinity for IGF. The majority of soluble IGFBP-3 found in circulation is secreted from hepatic non-parenchymal cells. IGFBP-3 potentiates EGF-EGFR-mediated cell growth, modulates adipogenesis, and regulates TGF-beta signaling, DNA damage, apoptosis, autophagy, and gene transcription.
High affinity insulin-like growth factor-I binding protein IGFBP inhibitor
| Chemical Name: | 1-(3,4-Dihydroxybenzoyl)-6,7-dihydroxy-3-isoquinolinecarboxylic acid |
| Purity: | ≥98% (HPLC) |
