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7 results for "IAP Inhibitors Small Molecules and Peptides" in Products

IAP Inhibitors: Small Molecules and Peptides

Inhibitors of apoptosis (IAP) are a family of proteins that are the major regulators of apoptosis through their interaction with the various components of the apoptotic signaling cascades. Originally discovered in baculovirus, the human homologs are sometimes described as baculovirus IAP repeat containing (BIRC) proteins.

There are a number of different IAPs including neuronal apoptosis inhibitory protein (NAIP or BIRC1), cellular IAPs (c-IAP-1 and c-IAP-2, or BIRC2 and BIRC3 respectively), ...

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Potent Lys-covalent pan-IAP inhibitor

Chemical Name: (R)-1-((S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamido)-2,3-dihydro-1H-inden-4-yl sulfurofluoridate
Purity: ≥95% (HPLC)
Potent Lys-covalent pan-IAP antagonist

Monovalent IAP antagonist

Chemical Name: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-phenoxy-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity: ≥97% (HPLC)
Selective cIAP1 Degrader (PROTAC®)

Potent pan IAP Degrader (PROTAC®)

Chemical Name: (2S,4S)-1-((S)-2-Cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)-4-(3-((5-(((S)-1-((2S,4R)-4-hydroxy-2-(((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-5-oxopentyl)oxy)phenoxy)-N-((R)-1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Purity: ≥98% (HPLC)
IAP-VHL Degrader

Functionalized IAP ligand for PROTACs®

Chemical Name: tert-Butyl ((S)-1-(((S)-1-cyclohexyl-2-((2S,4S)-4-(3-hydroxyphenoxy)-2-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)pyrrolidin-1-yl)-2-oxoethyl)amino)-1-oxopropan-2-yl)(methyl)carbamate
Purity: ≥95% (HPLC)
cIAP1 PROTAC® Degrader

Fluorescein labeled XIAP ligand for TR-FRET assay development

Purity: ≥95% (HPLC)
Fluorescein labeled XIAP ligand for TR-FRET assay development

Survivin suppressor

Alternate Names: sepantronium bromide
Chemical Name: 4,9-Dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-1H-naphth[2,3-d]imidazolium bromide
Purity: ≥98% (HPLC)
Survivin suppressor

High affinity XIAP antagonist; active in vivo

Chemical Name: N-Methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-[(1R)-1,2,3,4-tetrahydro-1-naphthalenyl]-L-prolinamide hydrochloride
Purity: ≥98% (HPLC)
High affinity XIAP antagonist; active in vivo
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