CD31/PECAM-1: Proteins and Enzymes

CD31/PECAM-1 is a heavily glycosylated transmembrane homophilic adhesion protein that is highly expressed on endothelial cells and at a lower level on platelets, granulocytes, macrophages, dendritic cells, T and B cells, and NK cells. It is required for the transepithelial migration of leukocytes. CD31 signaling increases the activation threshold of T cells and inhibits dendritic cell development. The extracellular domain of CD31 is released during endothelial cell apoptosis. This fragment circulates in the serum of patients suffering from myocardial infarction, acute ischaemic stroke, and multiple sclerosis, conditions that involve tissue damage and endothelial cell apoptosis.

R&D Systems, a Bio-Techne brand, offers a comprehensive range of PECAM-1 products including PECAM-1 antibodies, proteins, ELISAs and more - with species including human, mouse, porcine and rat. Use the filter on the left to drill down to the PECAM-1 product that best fits your needs.