255 results for "B-Raf" in Products
B-Raf Products
The Raf serine/threonine kinases are effectors of Ras that function as MAP3Ks in the ERK phosphorylation cascade. Mammals express three Raf proteins: Raf-1 (C-Raf); A-Raf; and B-Raf, strongly expressed in fetal brain and adult cerebrum. Mice with a targeted disruption of the B-raf gene die of vascular defects during mid-gestation. B-raf mutations have been found in two-thirds of malignant melanomas, with the single substitution V599E in the kinase domain the most frequent occurrence.
Potent B-Raf inhibitor
Potent B-Raf inhibitor
Recombinant Monoclonal Antibody
Potent Raf kinase inhibitor
PDGFRβ, B-Raf, c-Raf, FLT3 and KIT inhibitor
Potent and selective B-Raf, CDK16 and NEK9 inhibitor; anticancer; also targets human proteins in the SARS-CoV-2 interactome
Potent BRAF and CRAF inhibitor
Selective BRAF-V600E protein Degrader (uSMITE™)