15-PGDH/HPGD: Small Molecules and Peptides
HPGD, or 15-hydroxyprostaglandin dehydrogenase, is a NAD+-linked dehydrogenase that oxidizes the hydroxyl group at position 15 of prostaglandins to a ketone, resulting in a loss of biological activity. HPGD is a major enzyme for the catabolism of prostaglandins. The enzyme is a member of the short-chain alcohol dehydrogenase family of enzymes. HPGD is a cytosolic enzyme expressed in most tissues, with highest expression levels in placenta, lung, and kidney. It is inhibited by aspirin and nonsteroidal anti-inflammatory drugs. Defects in HPGD are a cause of hypertrophic osteoarthropathy.
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1 result for "15-PGDH/HPGD Small Molecules and Peptides" in Products
15-PGDH/HPGD: Small Molecules and Peptides
HPGD, or 15-hydroxyprostaglandin dehydrogenase, is a NAD+-linked dehydrogenase that oxidizes the hydroxyl group at position 15 of prostaglandins to a ketone, resulting in a loss of biological activity. HPGD is a major enzyme for the catabolism of prostaglandins. The enzyme is a member of the short-chain alcohol dehydrogenase family of enzymes. HPGD is a cytosolic enzyme expressed in most tissues, with highest expression levels in placenta, lung, and kidney. It is inhibited by aspirin and nonsteroidal anti-inflammatory drugs. Defects in HPGD are a cause of hypertrophic osteoarthropathy.
High affinity 15-PGDH inhibitor; promotes hematopoiesis and hepatocyte proliferation
| Chemical Name: | 2-(Butylsulfinyl)-4-phenyl-6-(2-thienyl)-thieno[2,3-b]pyridin-3-amine |
| Purity: | ≥98% (HPLC) |
