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Revolutionizing Gene Therapy Protein Expression Potency Assays

Fast 96-Sample Throughput for Comprehensive, Fully Quantitative Protein Analysis with the Leo System

Traditional protein expression potency methods, such as Western blot, ELISA, and cell-based assays, present well-known challenges. The Leo™ System powered by Simple Western™ Technology offers a breakthrough by enabling fully automated, quantitative, and ultra- sensitive protein analysis of up to 96 samples in a single three-hour run. 

  • Leo delivers precise, analytical-grade quantification of relative potency for gene therapy assays by processing up to 96 unique samples in a single run—with ample space for replicates and controls.
  • Whether measuring potency using a 7-point titration curve or quantifying protein expression with a 12-point standard curve, Leo ensures highly sensitive, reproducible data in a streamlined 3-hour workflow.
  • This high-throughput capability allows researchers to assess batch-to-batch consistency, stress-induced potency changes, and critical quality attributes (CQAs) like capsid ratios, purity, and empty/full content with confidence.
  • By reducing hands-on time and increasing data accuracy, Leo accelerates gene therapy development with the precision required for regulatory success.
  • Your existing Simple Western assay can be easily transferred to Leo with consistent results.

Gene Therapy Potency Assays on Leo and Jess