U 73343
Tocris Bioscience, part of Bio-Techne | Catalog # 4133
Analog of U 73122 (Cat. No. 1268)
Key Product Details
Description
Analog of U 73122 (Cat. No. 1268)
Product Description
U 73343 is an analog of U 73122; can be used as a negative control. Inhibits Panx1 currents in HEK cells. Also inhibits vasopressin- and GTPγS-induced Ca2+ influx in hepatocytes.Active Analog also available.
Product Specifications
Molecular Weight
466.66
Formula
C29H42N2O3
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-2,5-pyrrolidinedione
CAS Number
142878-12-4
PubChem ID
114825
InChI Key
CJHWFIUASFBCKN-ZRJUGLEFSA-N
SMILES
[H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(CCC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.67 | 10 with gentle warming | |
| Ethanol | 2.33 | 5 with gentle warming |
Preparing Stock Solutions
for U 73343
The following data is based on the product molecular weight 466.66
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.43 mL | 107.14 mL | 214.29 mL |
| 0.5 mM | 4.29 mL | 21.43 mL | 42.86 mL |
| 1 mM | 2.14 mL | 10.71 mL | 21.43 mL |
| 5 mM | 0.43 mL | 2.14 mL | 4.29 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Berven and Barritt Evidence obtained using single hepatocytes for inhibition by the phospholipase C inhibitor U73122 of store-operated Ca2+ inflow. Biochem.Pharmacol. 1995 PMID: 7763279
- Kataoka Activation of P2X7 receptors induces CCL3 production in microglial cells through transcription factor NFAT. J.Neurochem. 2009 PMID: 19014371
- Ma Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J.Pharmacol.Exp.Ther. 2009 PMID: 19023039
- Muto The putative phospholipase C inhibitor U73122 and its negative control, U73343, elicit unexpected effects on the rabbit parietal cell. J.Pharmacol.Exp.Ther. 1997 PMID: 9316850
Product Specific Notices for U 73343
For research use only
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