U 73122

Name: U 73122
Brand: Tocris Bioscience
SKU: 1268
Rating: 5 (3 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 1268

(3)

Citations (536)

COA / SDS

Phospholipase C inhibitor

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Product Description
Licensing Information
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Phospholipase C inhibitor

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Product Description

U 73122 is a phospholipase C inhibitor. Inhibits agonist-induced platelet aggregation with IC₅₀ values of 1-5 μM. Potently inhibits human polymorphonuclear neutrophil adhesion on biological surfaces (IC₅₀ < 50 nM) and exhibits antinociceptive activity in vivo. Also activates TRPM4 and inhibits TRPM3 channels.

Negative Control also available.

Licensing Information

Sold with the permission of Pharmacia

Product Specifications

Molecular Weight

464.65

Formula

C₂₉H₄₀N₂O₃

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

1-[6-[[(17β)-3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione

CAS Number

112648-68-7

PubChem ID

104794

InChI Key

LUFAORPFSVMJIW-ZRJUGLEFSA-N

SMILES

[H][C@]23[C@@]([C@]([H])(CC[C@@H]4NCCCCCCN5C(C=CC5=O)=O)[C@]4(C)CC3)([H])CCC1=CC(OC)=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Please refer to these solubility guidelines for U 73122 (Cat. No. 1268).

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Background References

References are publications that support the biological activity of the product.

Leitner Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. Br.J.Pharmacol. 2016 PMID: 27328745
Shi Phospholipase Cβ3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain. Proc.Natl.Acad.Sci.U.S.A. 2008 PMID: 19066214
Smith U-73122: a potent inhibitor of human polymorphonuclear neutrophil adhesion on biological surfaces and adhesion-related effector functions. J.Pharmacol.Exp.Ther. 1996 PMID: 8764366
Bleasdale Selective inhibition of receptor-coupled phospholipase C-dependent processes in human platelets and polymorphonuclear neutrophils. J.Pharmacol.Exp.Ther. 1990 PMID: 2147038